Functional Circulation

Company Description

We make perfusion machines for organ research. Our tools help scientists achieve discovery at the organ and develop new algorithms and devices for progress in transplantation. Discovery at the OrganDirectly control stimuli and observe responsesBuild confidence preclinicallySpend less compared to transplant and in vivo studiesMake the most of experimental surgery resources Progress in TransplantationRepair derangements of ischemiaEvaluate new preservation strategiesTransfect genes to express specific proteinsDeplete or inactivate passenger leukocytesBind to adhesion and co-stimulation sitesDeliver anti-inflammatory, anti-thrombotic, and anti-apoptosis drugsAssess biomarker prognostics of transplant functionEnable blockade of surface protein pathwaysInhibit endothelial activation and the complement cascadeRelax arteries and reduce edemaRestore cellular energy levelsDeliver RNA interference to block expression of pro-inflammatory proteinsPrecondition the pancreas to increase islet yields Beyond TransplantationOrgan physiologyEnhanced imaging of perfusion, metabolism, cancersCellular transplantationOrgan-blood interactionGenetically modified (knock-in and knock-out) organsAcute organ failureDrug absorption, distribution, metabolism, excretion, and toxicity